福岡大学研究者情報

■ 薬学部    助教 

渡辺　拓也  (ワタナベ　タクヤ)

  男

[ 研究分野 ]
  • 生物系薬学

件数 : 59件

研究業績

著書 ( 3件)
  1. 脳科学辞典（ニューロリギン）
    • 渡辺拓也、二井健介   ,  2013年8月
  2. 脳科学辞典（パッチクランプ法）
    • 渡辺拓也、二井健介   ,  2013年8月
  3. 脳科学辞典（ニューレキシン）
    • 渡辺拓也、二井健介   ,  2013年7月
論文 ( 52件)
  1. Sansoninto attenuates aggressive behavior and increases levels of homovanillic acid, a dopamine metabolite, in social isolation-reared mice
    • Takuya Watanabe, Hikari Iba, Hiroshi Moriyama, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki  Journal of Traditional and Complementary Medicine  ,  12/3,243-249  ,  2022年5月
  2. Ninjinyoeito exerts an antidepressant-like effect by enhancing the central noradrenergic system
    • Soichiro Tsutsumi,Takuya Watanabe,Akinobu Hatae,Marika Hirata,Hiroya Omori,Chise Taniguchi,Masaki Nagao,Kaori Kubota,Shutaro Katsurabayashi,Katsunori Iwasaki  Traditional & Kampo Medicine  ,  9/1,25-31  ,  2022年4月
  3. Kamishoyosan potentiates pentobarbital-induced sleep in socially isolated, ovariectomized mice
    • Nobuaki Egashira, Yu Goto, Hikari Iba, Rikako Kawanaka, Ryota Takahashi, Chise Taniguchi, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki  Journal of Ethnopharmacology  ,  281/,114585  ,  2021年12月
  4. Behavioral profile in a Dctn1G71A knock-in mouse model of Perry disease
    • Manami Deshimaru, Takayasu Mishima, Takuya Watanabe, Kaori Kubota, Mana Hosoi, Mariko Kinoshita-Kawada, Junichi Yuasa-Kawada, Maiko Ikeda, Masayoshi Mori, Yusuke Murata, Takaya Abe, Munechika Enjoji, Hiroshi Kiyonari, Shohta Kodama, Shinsuke Fujioka, Katsunori Iwasaki, Yoshio Tsuboi  Neuroscience Letters  ,  764/,136234  ,  2021年11月
  5. Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats
    • Nobuaki Egashira, Yu Goto, Ryota Takahashi, Hikari Iba, Shota Yamamoto, Takuya Watanabe, Kaori Kubota, Takehiro Kawashiri, Chise Taniguchi, Shutaro Katsurabayashi, Katsunori Iwasaki  Journal of Pharmacological Sciences  ,  147/1,114-117  ,  2021年9月
  6. Effects of two kinds of Kampo-hozai, ninjinyoeito and kamikihito, on mental disorder-like behaviors in senescence-accelerated mouse-prone 8 mice
    • Marika Hirata, Chise Taniguchi, Takuya Watanabe, Toru Horikawa, Yufuko Akizuki, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki  Traditional & Kampo Medicine  ,  2021年6月
  7. The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology
    • Shutaro Katsurabayashi, Kohei Oyabu, Kaori Kubota, Takuya Watanabe, Tomohisa Nagamatsu, Norio Akaike, Katsunori Iwasaki  Biochemical and Biophysical Research Communications  ,  560/,146-151  ,  2021年6月
  8. Inhibitory synaptic transmission is impaired at higher extracellular Ca 2+ concentrations in Scn1a +/- mouse model of Dravet syndrome
    • Kouya Uchino, Hiroyuki Kawano, Yasuyoshi Tanaka2, Yuna Adaniya, Ai Asahara, Masanobu Deshimaru, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki, Shinichi Hirose  Scientific reports  ,  11/1,10634  ,  2021年5月
  9. DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
    • Manami Deshimaru, Mariko Kinoshita-Kawada, Kaori Kubota, Takuya Watanabe, Yasuyoshi Tanaka, Saito Hirano, Fumiyoshi Ishidate, Masaki Hiramoto, Mitsuru Ishikawa, Yoshinari Uehara, Hideyuki Okano, Shinichi Hirose, Shinsuke Fujioka, Katsunori Iwasaki, Junichi Yuasa-Kawada,Takayasu Mishima, Yoshio Tsubo  International Journal of Molecular Sciences  ,  22/8,3985  ,  2021年4月
  10. マウスのガラス玉覆い隠し行動に対するメマンチン塩酸塩OD錠「ニプロ」の抑制効果
    • 長尾昌紀, 射場日佳里, 弟子丸眞実, 内野鉱也, 平田茉莉花, 堤宗一朗, 渡辺拓也, 岩崎克典  医学と薬学  ,  78/2,143-148  ,  2021年2月
  11. A Japanese herbal medicine attenuates anxiety-like behavior through GABA A receptor and brain-derived neurotrophic factor expression in a rat model of premenstrual syndrome
    • Hikari Iba, Takuya Watanabe, Saori Motomura, Kyoka Harada, Haruka Uesugi, Takenori Shibahara, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki  Journal of pharmacological sciences  ,  145/1,140-149  ,  2021年1月
  12. Valproic acid-exposed astrocytes impair inhibitory synapse formation and function
    • Kotomi Takeda, Takuya Watanabe, Kohei Oyabu, Shuntaro Tsukamoto, Yuki Oba, Takafumi Nakano, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki  Scientific reports  ,  11/1,23  ,  2021年1月
  13. Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
    • Motokazu Uchigashima, Kohtarou Konno, Emily Demchak, Amy Cheung, Takuya Watanabe, David G Keener, Manabu Abe, Timmy Le, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Yuka Imamura Kawasawa, Masahiko Watanabe, Kensuke Futai  Elife  ,  9/,e59545  ,  2020年12月
  14. Presynaptically silent synapses are modulated by the density of surrounding astrocytes
    • Kohei Oyabu, Kotomi Takeda, Hiroyuki Kawano, Kaori Kubota, Takuya Watanabe, N Charles Harata, Shutaro Katsurabayashi, Katsunori Iwasaki  Journal of pharmacological sciences  ,  144/2,76-82  ,  2020年10月
  15. Neuroligin3 splice isoforms shape inhibitory synaptic function in the mouse hippocampus.
    • Uchigashima, M., Leung, M., Watanabe, T., Cheung, A., Le, T., Pallat, S., Dinis, A., Watanabe, M., Kawasawa, Y. I., Futai, K  The Journal of biological chemistry  ,  295/25,8589-8595  ,  2020年6月
  16. Effect of Yokukansan and Yokukansankachimpihange on Aggressive Behavior, 5-HT Receptors and Arginine Vasopressin Expression in Social Isolation-Reared Mice
    • Hikari Iba, Takuya Watanabe, Kanae Matsuzawa, Maki Saimiya, Masako Tanaka, Masaki Nagao, Hiroshi Moriyama, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki  Biological and Pharmaceutical Bulletin  ,  42/12,2009-2015  ,  2019年12月
  17. Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells.
    • Ikuya Kimura, Shinya Dohgu,Fuyuko Takata, Junichi Matsumoto, Takuya Watanabe, Takuro Iwao, Atsushi Yamauchi, Yasufumi Kataoka  Neuroscience Letters  ,  2019年10月
  18. Effect of Lactobacillus paracasei A221‐fermented ginseng on impaired spatial memory in a rat model with cerebral ischemia and β‐amyloid injection
    • Masaki Nagao, Satoshi Yamano, Naoki Imagawa, Kentaro Igami, Toshitsugu Miyazaki, Hisatomi Ito, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki  Traditional & Kampo Medicine  ,  6/2,96-104  ,  2019年8月
  19. Hippocampal neurons in direct contact with astrocytes exposed to amyloid β25-35 exhibit reduced excitatory synaptic transmission
    • Kohei Oyabu, Hiroki Kiyota, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki  IBRO Reports  ,  7/,34-41  ,  2019年7月
  20. 不眠に処方される漢方薬の作用機序
    • 岩崎克典、長尾昌紀、森山博史、渡辺拓也  Progress in Medicine  ,  38/10,13-19  ,  2018年10月
  21. The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia.
    • Ai Nogami-Hara, Masaki Nagao, Kotaro Takasaki, NobuakiEgashira, Risako Fujikawa, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Funda Bolukbasi Hatip, Izzettin Hatip-Al-Khatib, Katsunori Iwasaki  Journal of Ethnopharmacology  ,  214/,190-196  ,  2018年3月
  22. The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors: Implications for obsessive-compulsive disorder.
    • Nobuaki Egashira, Naoki Kubota, Yu Goto, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki  Pharmacology, Biochemistry, and Behavior  ,  165/,9-13  ,  2018年2月
  23. Astrocytes with previous chronic exposure to amyloid β-peptide fragment 1-40 suppress excitatory synaptic transmission.
    • Kawano H, Oyabu K, Yamamoto H, Eto K, Adaniya Y, Kubota K, Watanabe T, Hirano-Iwata A, Nabekura J, Katsurabayashi S, Iwasaki K.  Journal of Neurochemistry  ,  143/6,624-634  ,  2017年12月
  24. The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB.
    • Kaori Kubota, Haruka Fukue, Hitomi Sato, Kana Hashimoto, Aya Fujikane, Hiroshi Moriyama, Takuya Watanabe, Shutaro Katsurabayashi, Mosaburo Kainuma, Katsunori Iwasaki  Frontiers in Pharmacology  ,  2017年11月
  25. アリピプラゾール錠・OD錠・散・内服液「ニプロ」のマウスを用いた抗精神病効果の検討
    • 長尾昌紀、森山博史、大藪康平、安谷屋友菜、胸元　芳、渡辺拓也、岩崎克典  新薬と臨床  ,  66/5,611-620  ,  2017年6月
  26. Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer's disease rat model
    • Hiroshi Moriyama,Takuya Watanabe,Kotaro Takasaki,Masaki Nagao,Kaori Kubota,Shutaro Katsurabayashi,Nobuaki Egashira,Katsunori I  Traditional & Kampo Medicine  ,  4/1,38-45  ,  2017年4月
  27. Effect of hachimijiogan on memory impairment induced by beta-amyloid combined with cerebral ischemia in rats.
    • Hiroshi Moriyama,Takayasu Mishima,Mosaburo Kainuma,Takuya Watanabe,Masaki Nagao,Kotaro Takasaki,Kaori Kubota,Shutaro Katsurabayashi,Yoshio Tsuboi,Katsunori Iwasaki  Traditional & Kampo Medicine  ,  4/1,51-54  ,  2017年4月
  28. Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats.
    • Egashira N, Iba H, Kuwano H, Kawanaka R, Nagao M, Moriyama H, Watanabe T, Kubota K, Katsurabayashi S, Iwasaki K  Journal of Pharmacological Sciences  ,  131/4,279-283  ,  2016年8月
  29. 神経栄養因子の補充療法に替わる抑肝散による認知症治療法の構築
    • Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki  BIO Clinica  ,  31/4,87-92  ,  2016年4月
  30. Nifedipine prevents sodium caprate-induced barrier dysfunction in human epidermal keratinocyte cultures.
    • Uchino Yoshihiro, MATSUMOTO Jyun-Ichi, WATANABE Takuya, Hamabashiri Masato, Tsuchiya Takashi, Kimura Ikuya, YAMAUCHI Atsushi, KATAOKA Yasufumi  Biological and Pharmaceutical Bulletin  ,  38/6,926-929  ,  2015年
  31. Positioning of AMPA receptor-containing endosomes regulates synapse architecture.
    • da Silva ME, Adrian M, Schatzle P, Lipka J, Watanabe T, Cho Sukhee, Futai K, Wierenga CJ, Kapitein LC, Hoogenraad CC  Cell reports  ,  13/5,933-943  ,  2015年11月
  32. Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons.
    • Mao Wenjie, Watanabe Takuya, Cho Sukhee, Frost L. Jeffrey, Truong Tina, Zhao Xiaohu, Futai Kensuke  European Journal of Neuroscience  ,  41/8,1025-1035  ,  2015年4月
  33. Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line
    • YASUTAKA Yuki, WATANABE Takuya, NAKASHIMA Akio, Matsumoto Junichi, Fytagami Kojiro, YAMAUCHI Atsushi, KATAOKA Yasufumi  FEBS LETTERS  ,  589/2,263-268  ,  2015年1月
  34. Injection of specific amyloid-beta oligomers (beta1-40:beta1-42=10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis.
    •   Neurological Research  ,  35/8,798-803  ,  2013年10月
  35. Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden
    • Takuya Watanabe, Kotaro Takasaki, Norito Yamagata, Michihiro Fujiwara, Katsunori Iwasaki  Neuroscience Letters  ,  536/,74-79  ,  2013年3月
  36. Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
    • 渡辺　拓也、道具　伸也、高田　芙友子、中島　章雄、二神　幸次郎、山内　淳史、片岡　泰文  Biological & Pharmaceutical Bulletin  ,  36/3,492-495  ,  2013年1月
  37. Atorvastatin stimulates neuroblastoma cells to induce neurite outgrowth by increasing cellular prion protein expression
    • 渡辺　拓也、中島　章雄、山内　淳史、片岡　泰文  Neuroscience letters  ,  531/2,114-119  ,  2012年12月
  38. Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis.
    •   Journal of Inflamation  ,  9/1,44  ,  2012年11月
  39. Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease.
    • Naoki Uchida, Kotaro Takasaki, Yuri Sakata, Ai Nogami, Hiroshi Oishi, Takuya Watanabe, Taro Shindo, Nobuaki Egashira, Kaori Kubota, Shutaro Katsurabayashi, Kenichi Mishima, Michihiro Fujiwara, Ryoji Nishimura, Katsunori Iwasaki  Phytotherapy research  ,  27/7,966-972  ,  2012年8月
  40. Involvement of the cellular prion protein in the migration of brain microvascular endothelial cells.
    • Watanabe T, Yasutaka Y, Nishioku T, Kusakabe S, Futagami K, Yamauchi A, Kataoka Y.  Neurosci Lett.  ,  496/2,121-124  ,  2011年6月
  41. Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood-brain barrier in mice.
    • Yamauchi A, Dohgu S, Takata F, Watanabe T, Nishioku T, Matsumoto J, Ohkubo Y, Shuto H, Kataoka Y.  Life Sci.  ,  88/11-12,529-534  ,  2011年3月
  42. Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1.
    • Dohgu S, Takata F, Matsumoto J, Oda M, Harada E, Watanabe T, Nishioku T, Shuto H, Yamauchi A, Kataoka Y.  Microvasc Res.  ,  81/1,103-7  ,  2010年10月
  43. Cyclosporin A induces hyperpermeability of the blood-brain barrier by inhibiting autocrine adrenomedullin-mediated up-regulation of endothelial barrier function.
    • Dohgu S, Sumi N, Nishioku T, Takata F, Watanabe T, Naito M, Shuto H, Yamauchi A, Kataoka Y.  Eur J Pharmacol.  ,  644/1-3,5-9  ,  2010年10月
  44. Development of an ultra-rapid diagnostic method based on heart-type fatty acid binding protein levels in the CSF of CJD patients.
    • Matsui Y, Satoh K, Mutsukura K, Watanabe T, Nishida N, Matsuda H, Sugino M, Shirabe S, Eguchi K, Kataoka Y.  Cell Mol Neurobiol.  ,  30/7,991-9  ,  2010年10月
  45. Disruption of the blood-brain barrier in collagen-induced arthritic mice.
    • Tsuyoshi Nishioku, Atsushi Yamauchi, Fuyuko Takata, Takuya Watanabe, Koki Furusho, Hideki Shuto, Shinya Dohgu, Yasufumi Kataoka  Neuroscience Letter  ,  482/3,208-211  ,  2010年10月
  46. Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
    • Watanabe T, Iwasaki K, Takasaki K, Yamagata N, Fujino M, Nogami A, Ii M, Katsurabayashi S, Mishima K, Fujiwara M.  J Neurosci Res.  ,  88/9,1908-17  ,  2010年6月
  47. Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia.
    • Sumi N, Nishioku T, Takata F, Matsumoto J, Watanabe T, Shuto H, Yamauchi A, Dohgu S, Kataoka Y.  Cell Mol Neurobiol.  ,  30/2,247-53  ,  2010年3月
  48. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism.
    • Hayakawa K, Irie K, Sano K, Watanabe T, Higuchi S, Enoki M, Nakano T, Harada K, Ishikane S, Ikeda T, Fujioka M, Orito K, Iwasaki K, Mishima K, Fujiwara M.  Biol Pharm Bull.  ,  32/9,1538-44  ,  2009年9月
  49. Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease.
    • Watanabe T, Yamagata N, Takasaki K, Sano K, Hayakawa K, Katsurabayashi S, Egashira N, Mishima K, Iwasaki K, Fujiwara M.  Brain Res.  ,  1249/,222-8  ,  2009年1月
  50. Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats.
    • Watanabe T, Iwasaki K, Ishikane S, Naitou T, Yoshimitsu Y, Yamagata N, Ozdemir MB, Takasaki K, Egashira N, Mishima K, Fujiwara M.  J Pharmacol Sci.  ,  106/1,84-91  ,  2008年1月
  51. Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats.
    • Iwasaki K, Egashira N, Hatip-Al-Khatib I, Akiyoshi Y, Arai T, Takagaki Y, Watanabe T, Mishima K, Fujiwara M.  Brain Res.  ,  1097/1,216-23  ,  2006年6月
  52. Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice.
    • Egashira N, Iwasaki K, Takashima A, Watanabe T, Kawabe H, Matsuda T, Mishima K, Chidori S, Nishimura R, Fujiwara M.  Brain Res.  ,  1059/1,7-12  ,  2005年10月
学会発表・講演 (4件)
  1. バルプロ酸暴露アストロサイトのシナプス形成・伝達に対する影響
    • 渡辺 拓也、武田 琴水、大藪 康平、内野 鉱也、窪田 香織、桂林 秀太郎、岩崎 克典   ,  日本薬学会第１４２年会  ,  2022年3月
  2. 易怒性・攻撃性に対して抑制効果を示す漢方薬の作用機序探索
    • 第３８回和漢医薬学会学術大会　学術貢献賞受賞講演  ,  2021年9月
  3. 発達障害で認められる社会性行動障害の治療を目的とした漢方薬の探索
    • 渡辺拓也、射場日佳里、松澤香奈絵、川井　優、才宮万季、冨高真弘、入佐紘司、窪田香織、桂林秀太郎、岩崎克典   ,  生体機能と創薬シンポジウム２０１８  ,  2018年8月
  4. アルツハイマー病モデル動物の空間記憶障害における八味地黄丸の効果
    • 渡辺拓也、岩崎克典   ,  医療薬学フォーラム２０１７  ,  2017年7月
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